2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W096106
    CH2COOH-PEG6-CH2COOH 83824-29-7
    CH2COOH-PEG6-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    CH2COOH-PEG6-CH2COOH
  • HY-140322
    DBCO-mPEG (MW 30kDa)
    DBCO-mPEG (MW 30kDa) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-mPEG (MW 30kDa) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-mPEG (MW 30kDa)
  • HY-W096129
    Cl-PEG4-acid 158553-98-1 98.0%
    Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cl-PEG4-acid
  • HY-161020
    m-PEG12-OTs 2103241-71-8
    m-PEG12-Ots is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG12-OTs
  • HY-141388
    Bromoacetamido-PEG3-C2-Boc 1807537-33-2
    Bromoacetamido-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG3-C2-Boc
  • HY-140666
    Azide-PEG-azide (MW 10000)
    Azide-PEG-azide (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG-azide (MW 10000) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG-azide (MW 10000)
  • HY-135958
    DBCO-NHCO-PEG6-Biotin 3081794-36-4 98.44%
    DBCO-NHCO-PEG6-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG6-Biotin
  • HY-124011A
    m-PEG3-aldehyde (stabilized with BHT) 356066-46-1 98.00%
    m-PEG3-aldehyde (stabilized with BHT) is a PROTAC linker that belongs to the PEG class and can be used in the synthesis of PROTACs.
    m-PEG3-aldehyde (stabilized with BHT)
  • HY-140497
    Hydroxy-PEG2-CH2COOH 51951-04-3
    Hydroxy-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG2-CH2COOH
  • HY-130200
    NH2-PEG8-OH 352439-37-3
    NH2-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG8-OH
  • HY-W096080
    t-Butyl acetate-PEG2-CH2COOH 883564-93-0
    t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Butyl acetate-PEG2-CH2COOH
  • HY-138396
    Rhodamine B PEG2-NH2
    Rhodamine B PEG2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Rhodamine B PEG2-NH2
  • HY-140008
    DOTA-PEG5-amine 98.0%
    DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DOTA-PEG5-amine
  • HY-135926
    Cbz-NH-PEG1-CH2CH2COOH 1205751-19-4 98.80%
    Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cbz-NH-PEG1-CH2CH2COOH
  • HY-138395
    DSPE-PEG6-Mal
    DSPE-PEG6-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG6-Mal
  • HY-133475
    TCO-PEG5-maleimide 99.46%
    TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG5-maleimide
  • HY-130387
    Propargyl-PEG4-Tos 875770-32-4 99.25%
    Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-Tos
  • HY-W006629
    (4S)​-4-Hydroxy-D-proline methyl ester hydrochloride 481704-21-6 98.0%
    (4S)-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (4S)-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (4S)​-4-Hydroxy-D-proline methyl ester hydrochloride
  • HY-141232
    Decaethylene glycol 5579-66-8 99.13%
    Decaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Decaethylene glycol
  • HY-140520
    N-(acid-PEG3)-N-bis(PEG3-azide) 2182602-17-9 98.07%
    N-(acid-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(acid-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(acid-PEG3)-N-bis(PEG3-azide)
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.